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IN VITRO PROPERTIES OF [18F]NAV4694: DYNAMIC RANGE, DISPLACEMENT, AND WHITE‐MATTER BINDING
Author(s) -
Zimmer Eduardo Rigon,
Leuzy Antoine,
Aliaga Arturo,
Cheewakriengkrai Laksanun,
Mohades Sara,
Schilling Lucas Porcello,
Benedet Andrea Lessa,
Schirrmacher Esher Susanne,
Soucy JeanPaul,
Guiot MarieChristine,
Reininger Cornelia,
Gauthier Serge,
RosaNeto Pedro
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.485
Subject(s) - white matter , human brain , hippocampus , nuclear medicine , in vitro , prefrontal cortex , cortex (anatomy) , cerebellum , posterior cingulate , binding site , chemistry , medicine , pathology , neuroscience , biology , magnetic resonance imaging , biochemistry , cognition , radiology
Background: The locus coeruleus (LC) is a brainstem nucleus that has widespread projections to modulate states of attention. It has been shown that tau pathology is frequently seen in the LC in individual under 30 years of age, suggesting Alzheimer’s disease(AD)-associated tau pathology begins in the LC. The purpose of this study was to investigate age-related and AD-associated change in the LC using magnetic resonance (MR) imaging. Methods: Subjects were 16 young subjects (yCN, mean years of age (range): 23.1(20-33) y.o.), 48 PiB(-) older cognitively normal subjects (oCN, 69.4(60-79)y.o., MMSE mean(range): 28.8(25-30)), 10 PiB(+) patients with mild cognitive impairment (MCI, 76.2(66-82) y.o., MMSE: 26.2(24-28)), and 12 PiB(+) patients with Alzheimer’s disease (AD, 73.8(64-82) y.o., MMSE: 21.8(17-28)) who underwent T1wieghted high resolution MR imaging of the brain stem and 3D T1weighted whole brain MR imaging. The brain stem image was coregistrated to the whole brain image and spatially normalized with DARTEL. Regions of interest (ROI) were placed on the hyperintensity derived from neuromelanin (NM) of the LC at -31.0 to -14.0 in Z coordinate in the MNI stereotactic space. The contrast ratio (CR) of the LC was calculated as CRLC 1⁄4(SLC SDS)/SDS, where SLC and SDS are the signal intensities of the LC and superior cerebellar peduncle decussation, respectively. Results: yCN represented higher CRLC in the LC (right and left, Z1⁄4-23.5 to -14.0, mid-rostral) compared to oCN (p<0.05). The CRLC(right Z1⁄4-28.5 to -21.5, caudal to mid) was inversely correlated with age in oCN (p<0.02). Significant difference of the CRLC between oCN and AD was observed in left Z1⁄4-31.0 to -24.0 and right -28.5 to -19.0 (p<0.05). However the differences did not reach to significant level after adjusting age. Asymmetry of CRLC (left > right) was larger in the caudal side especially in MCI and AD. Conclusions: The results suggest that NM in the LC shows asymmetrical variation and decrease with aging from 20 to 80 years old independent from amyloid deposition. There might be no change of NM in the LC over the age-related decrease in MCI and relatively mid AD.