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P1‐225: CLINICAL MEMORY PERFORMANCE COVARIES WITH CORTICAL THINNING OF THE DEFAULT MODE NETWORK IN ALZHEIMER'S DISEASE: THE SUNNYBROOK DEMENTIA STUDY
Author(s) -
Nestor Sean Michael,
Zhao Jiali,
Masellis Mario,
Ramirez Joel,
Black Sandra E.
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.464
Subject(s) - dementia , default mode network , white matter , psychology , neuropsychology , audiology , wechsler adult intelligence scale , grey matter , neuroscience , cognition , magnetic resonance imaging , medicine , disease , pathology , radiology
nucleus accumbens volume to disinhibition, and caudate nucleus to nighttime behavior disturbances. Conclusions: Caudate nucleus, globus pallidus and nucleus accumbens were more severely affected in bvFTD than in AD and controls. The observed volume differences of these DGM structures supports the idea that next to frontal cortical atrophy, DGM structures, as parts of the frontal circuits, are damaged in bvFTD rather than in AD.