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P1‐195: ANTEROGRADE AMNESIA WITH UNILATERAL HIPPOCAMPAL LESION IN NEURO‐BEHCET's DISEASE
Author(s) -
Shin ByoungSoo,
Kim TaeWoo,
You AeYoung
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.433
Subject(s) - anterograde amnesia , amnesia , fornix , hippocampus , lesion , medicine , neuroscience , basal forebrain , vasculitis , thalamus , neuropsychology , psychology , pathology , central nervous system , disease , cognition , psychiatry
Background: NBD can be classified as parenchymal lesions that involved brain stem, basal ganglia and thalamus with meningoencephalitic presentation. Non-parenchymal lesions which usually affects major intracranial vessels with frequent involvement of the venous sinuses, cerebral veins and rarely intracranial arteries. Non-parenchymal NBD is secondary to thrombosis of brain venous sinus and occasionally to arterial vasculitis. Several reports have documented cognitive impairment of Neuro-Behcet’s disease (NBD). Studies that have collected objective neuropsychological data suggest characteristic patterns of deficits, involving mainly memory, attention and executive functioning. Methods:We present a patient with NBD who has unilateral vasculitis lesion at right hippocampus whose clinical feature mimicked that of diencephalic or basal forebrain amnesia. Detailed neuropsychological evaluation demonstrated that the patient’s problems were limited to sever anterograde amnesia and forntal/excutive dusfunction. Results: Findings in the present patient suggest the hippocampus plays a key role in the formation of new memory and as a component of the Papez circuit, which is composed of the hippocampus, fornix, mamllary body, mammillo-thalamic tract, anterior thalamus and cingulated gyrus. Conclusions: This report represents NBD with selective anterograde amnesia with excutive dysfunction caused by unilateral vasculitic lesions in right hippocampus.