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P1‐182: THE EFFECT OF PSYCHOLOGICAL DISTRESS AND PERSONALITY TRAITS ON COGNITIVE TEST PERFORMANCES AND THE RISK OF DEMENTIA IN PATIENTS WITH MILD COGNITIVE IMPAIRMENT
Author(s) -
Ramakers Inez,
Honings Steven,
Aalten Pauline,
Visser Pieter Jelle,
Ponds Rudolf,
Verhey Frans R.J.
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.420
Subject(s) - dementia , psychology , clinical psychology , verbal fluency test , personality , distress , cognition , personality changes , neuropsychology , psychiatry , disease , medicine , social psychology
subject memory impairment (SMI) in identifying those at risk of developing AD has been previously investigated. SMI appears most related to mood, rather than cognition. A recent study published an association between amyloid load at the time of self-reported memory problems (Rowe et al., 2010); however, another study failed to validate these findings (Buckley et al, 2013). To our knowledge, no study has looked at the relationship between SMI and amyloid load a decade later. In this study we aimed to determine whetherSMI is related to b-amyloid load measured a decade later. Methods: We examined the association between SMI (using 4 specific questions on self-perceived memory) determined in 2002, in 95 cognitively normal participants who also had cerebral b-amyloid load measured (by 18 F-Fluorobetaben Positron Emission Tomography) in 2012. Given previous associations of mood with SMI, we also examined the relationship between SMI and affect (Hassle score, CESD). Results:No significant associations were found between the SMI groups identified using 4 questions on memory and 18 F -SUVR measured ten years later. Associations were found between SMI and depression and anxiety. Analysis of which aspects of these mood scales were driving this association found the depressive scale items of clear-headed, p 1⁄4 0.012 and confused p 1⁄4 0.020 and the anxiety item of confused, p 1⁄4 0.021 were the drivers of subjective memory complaint. Conclusions: Subjective memory impairment was found to have no relationship with amyloid load determined a decade later, suggesting their limited clinical use. However, others have found such a relationship on cross-sectional studies using different methods of identifying SMI. It may be more specific questioning is needed to select for those with true pathological memory change. Further research is needed to investigate subjective impairment across different aspects of memory and cognition, and their relationship to Alzheimer’s pathology and progression to disease. It may be that multivariate modelling which weights memory reports with concurrent symptomatology and risk factors will have the greatest value in providing an early marker of those at risk of cognitive decline.