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P1‐147: A PROSPECTIVE, SYSTEMATIC LITERATURE REVIEW AND META‐ANALYSES TO EVALUATE GLOBAL AND REGIONAL BRAIN VOLUMES BY STRUCTURAL MRI AS BIOMARKERS OF ALZHEIMER'S DISEASE (AD) PROGRESSION
Author(s) -
Liu Enchi,
Ashaye Ajibade,
Travers Karin,
Strand Lauren,
Olsson Kelly,
Tanna Gian Luca,
Wyman Bradley T.,
Booth Kevin,
Styren Scot,
Brashear Robert H.,
Einstein Steven,
Novak Gerald
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.384
Subject(s) - atrophy , meta analysis , dementia , brain size , medicine , cognitive decline , alzheimer's disease , cognition , psychology , disease , cardiology , pathology , magnetic resonance imaging , psychiatry , radiology
and MMSE was found in the occipital lobes for the combined AD+MCI+HC (Pearson 0.82, p1⁄40.0465) and AD (Pearson 0.99, p1⁄40.01) groups. Conclusions:Based on relatively small number of studies, no apparent relationship between change on brain amyloid burden and cognition in AD was found. In contrast, the negative correlation seen in MCI suggests that PiB PET changes may be a useful biomarker in earlier disease phases. The significant finding in the correlation between changes in amyloid deposition in the occipital lobe and MMSE warrants further study. Limitation included the paucity of studies having longitudinal data on both brain amyloid burden and clinical measures and heterogeneity amongst studies.