P1‐083: NOREPINEPHRINE PROVIDES SHORT‐TERM NEUROPROTECTION AGAINST BETA‐AMYLOID BY REDUCING OXIDATIVE STRESS INDEPENDENT OF NRF2 ACTIVATION

plaques (p 1⁄4 0.009). In the AD samples, statistically significant differences in the g-secretase activity were not observed with respect to disease severity (mild, moderate and severe AD according to neurofibrillary pathology). Conversely, b-secretase activity was unaltered in iNPH samples with or without Ab plaques, while it was significantly increased in relation to disease severity in the AD patients. Conclusions: These results show for the first time increased g-secretase but not b -secretase activity in the biopsy samples from the frontal cortex of iNPH patients with ADlike A b pathology. Conversely, the opposite was observed in these secretase activities in AD patients with respect to neurofibrillary pathology. Despite the resemblances in the A b pathology, iNPH and AD patients appear to have marked differences in the cellular mechanisms responsible for the production of Ab.