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P1‐017: ELEMENTS OF METABOLIC SYNDROME IN AN URBAN SAMPLE WITH MILD COGNITIVE IMPAIRMENT
Author(s) -
Benabou Karen,
Brennan Lauren,
Lippa Carol,
Giovannetti Tania,
DelanoWood Lisa,
Nation Daniel A.,
Bondi Mark,
Au Rhoda,
Libon David J.
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.252
Subject(s) - metabolic syndrome , medicine , neurocognitive , incidence (geometry) , diabetes mellitus , body mass index , dementia , population , neuropsychology , pediatrics , disease , cognition , obesity , endocrinology , psychiatry , physics , environmental health , optics
and neurodegenerative pathologies, including TAR-DNA-binding protein43 (TDP-43). Anti-phospho-TDP-43 (pTDP-43) is suggested to be a marker for granulovacuolar degeneration (GVD).Methods:H ippocampal sections (9mm thick) from 235 brains donated for the population-based clinicopathological Cambridge City over 75 Cohort Study (CC75C) were stained with haematoxylin-eosin (HE) and antiphosho-TDP-43. HScl was defined as no more than one identifiable pyramidal neuron in each CA1 field of view at 200-fold magnification of a HE-section, not explained by an infarct, and no obvious neuron loss in other hippocampal areas. GVD was assessed on both HEand pTDP-43-stained sections. TDP-43 and GVD pathology severity was scored in various hippocampal areas and the entorhinal and temporal cortex by layer as none, one, mild, moderate or severe. Measures for Alzheimer’s disease (AD)-type and vascular pathologies were based on the Consortium to Establish a Registry of AD (CERAD) protocol. Clinical data was obtained from CC75C surveys. Results: Eleven HScl cases (4.7%) were identified, accounting for 6.7% of those with dementia and 10.8% of those aged 95 years or more. All evaluated HScl cases showed TDP-43-positive inclusions in the dentate gyrus (p<0.001 compared to non-HScl cases). Clinically, most HScl cases were diagnosed as having Alzheimer’s dementia. However, HScl was not associated with any CERAD parameter for AD or cerebrovascular pathology. Severity of TDP-43 pathology was similar in HScl cases with Braak stage V-VI (n1⁄44) and those without (n1⁄45). HScl did not associate with GVD. GVD was not reliably stained by anti-pTDP-43.Similar results were obtained from a second population-based study. Conclusions: Our results indicate that in the general elderly population HScl is strongly associated with hippocampal TDP-43 pathology and independent from AD and vascular disease.