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IC‐P‐217: CSF β‐AMYLOID AND PHOSHO‐TAU INTERACTIONS ON BRAIN STRUCTURE IN PRECLINICAL AD
Author(s) -
Fortea Juan,
Vilaplana Eduard,
Alcolea Daniel,
CarmonaIragui Maria,
SánchezSaudinós Maria Belén,
Sala Isabel,
AntónAguirre Sofía,
GonzálezOrtiz Sofía,
Medrano Santiago,
Pegueroles Jordi,
Morenas Estrella,
Clarimón Jordi,
Blesa Rafael,
Lleó Alberto
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.225
Subject(s) - alzheimer's disease neuroimaging initiative , cerebrospinal fluid , neuroimaging , correlation , medicine , amyloid β , oncology , pathology , psychology , disease , neuroscience , cognitive impairment , geometry , mathematics
of frozen tissue slices (20 mm thick). Imaging plates were scanned using BAS5000 Phosphoimager (Fuji-Film), with total binding obtained for all regions of interest. Results: No significant differences between control and AD groups were noted in terms of sex distribution, age and postmortem delay (P < 0.05). Binding of [18 F]T807 was significantly higher in AD tissue, as compared to CN [HIPP (P < 0.01), PFC (P < 0.01), IPC (P < 0.05), PCC (P < 0.05], with the magnitude of difference highest in the IPC. Conclusions: [18 F]T807 successfully differentiated CN and AD post-mortem tissue, with binding substantially higher in AD, particularly in the IPC. Our findings support the current perspective on [18 F]T807 as a promising tau molecular imaging agent.