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IC‐P‐209: BRAIN VOLUMES DIFFER BETWEEN CAUCASIAN AND CHINESE COGNITIVELY NORMAL ELDERLY CONTROLS
Author(s) -
Zhang Linda,
TakFai Cheung Raymond,
Pa Judy,
Yokoyama Jennifer S.,
Lee Allen K.S.,
Chu Leungwing,
Rosen Howard,
Miller Bruce,
Fung Mak Henry Ka
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.217
Subject(s) - neuroimaging , alzheimer's disease neuroimaging initiative , confounding , ethnic group , medicine , cohort , psychology , disease , brain size , gerontology , cognitive impairment , magnetic resonance imaging , neuroscience , radiology , sociology , anthropology
Results: Diagnostic criteria suggested that principal components and factors analysis identified 8 and 13 spatial patterns of similar cortical thicknesses, respectively. Individual spatial patterns represented parts of known functional networks, including Broca’s and Wernicke’s areas, visual cortex, sensorimotor cortex, the default mode network, the episodic memory system, and prefrontal cortex. Intuitive associations between increasing age and decreasing cortical thickness within specific cortical regions were evident in post hoc analysis.Conclusions: In this structural covariance analysis of a middle-aged group, there is evidence for a relatively small number of distinct, biologically-plausible spatial patterns of covarying cortical thickness, and these spatial patterns show expected thinning with age. PCA and FA with criteria for determining the true number of significant and distinct spatial patterns is a viable approach for structural covariance analysis.