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IC‐P‐177: GENETIC FINDINGS USING ADNI MULTIMODAL QUANTITATIVE PHENOTYPES: A REVIEW OF PAPERS PUBLISHED IN 2013
Author(s) -
Yao Xiaohui,
Chen Rui,
Kim Sungeun,
Yan Jingwen,
Du Lei,
Nho Kwangsik T.,
Foroud Tatiana,
Moore Jason,
Weiner Michael Walter,
Saykin Andrew J.,
Shen Li
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.184
Subject(s) - genome wide association study , genetic association , computational biology , neuroimaging , phenotype , genotyping , biology , imaging genetics , genotype , genetics , gene , single nucleotide polymorphism , neuroscience
q1⁄40.06/ rs4072391 x rs261752 p 1⁄42.9x10 -5 q 1⁄40.08). Conclusions: Previous studies have shown increased immunoreactivity of classical complement molecules, such as C9, surrounding brain Ab aggregates, suggesting a link between them. The IL6 receptor can be found in a soluble form (sIL6R), which binds to IL6, enhancing its activity. Studies have shown decreased CSF sIL-6R levels in AD patients, suggesting an association with lower efficacy of IL6 in the CNS. We suggest that an interaction between these genes can affect Ab accumulation in the brain. Further analyses are required in order to define the genetic interaction between those markers and validate their role in the disease.