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IC‐P‐176: EPISTASIS ANALYSES INDICATE ASSOCIATION BETWEEN CEREBRAL AMYLOID DEPOSITION AND GENES INVOLVED IN IMMUNO‐RESPONSE
Author(s) -
Benedet Andréa,
Lemay Philippe,
Mathotaarachchi Sulantha Sanjeewa,
Mohades Sara,
Zimmer Eduardo Rigon,
DionneLaporte Alexandre,
Picard Cynthia,
Shin Monica,
Wang Seqian,
Parent Maxime,
Schilling Lucas Porcello,
Carbonnell Felix,
Beaudry Thomas,
Fonov Vladmir,
Gauthier Serge,
Rouleau Guy,
Poirier Judes,
RosaNeto Pedro
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.183
Subject(s) - neuroinflammation , biomarker , apolipoprotein e , population , biology , medicine , oncology , immunology , neuroscience , disease , genetics , environmental health
groups had smaller thalamic volumes than non-carriers. No significant group differences were evident for other imaging measures. Conclusions: Lower thalamic volumes and altered diffusivity were evident in FAD MCs compared to non-carriers at a stage when whole brain volumes and atrophy rates were similar. Thalamic FA in particular merits further investigation as a marker of early disease progression in larger FAD cohorts.