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IC‐P‐170: COMT AND BDNF GENE INTERACTIONS PREDICT BRAIN STRUCTURE IN AGEING
Author(s) -
Mortby Moyra E.,
Das Debjani,
Anstey Kaarin Jane,
Janke Andrew,
Easteal Simon Easteal,
Sachdev Perminder S.,
Cherbuin Nicolas
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.177
Subject(s) - catechol o methyl transferase , grey matter , white matter , brain derived neurotrophic factor , brain structure and function , psychology , neuroscience , cognition , medicine , neurotrophic factors , allele , magnetic resonance imaging , biology , genetics , gene , receptor , radiology
explored correlation of CSF biomarkers with subregional measurements. Results: Hippocampal subfield volumes as well as thickness in extrahippocampal cortices were significantly reduced in the entire MCI cohort relative to OHC, with CA1 showing the largest group effect. However, when just eMCI was compared to OHC, the only significant difference was found in PRC thickness. Within MCI, PRC thickness (BA35) had the strongest significant positive correlation with CSF pTau, whereas CA1 volume had the strongest significant negative correlation with CSF Ab. Conclusions: Subregional MTL measurements showed significant group effect only in PRC for eMCI patients, consistent with the earliest appearance of pathology in this region (Braak Stage I). With further disease progression in lMCI, significant effects appeared in ERC, SUB as well as hippocampal subfields CA and DG, with CA1 showing the strongest group separation (see figure).