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IC‐P‐162: THE RELATIONSHIP BETWEEN FUNCTIONAL CONNECTIVITY CHANGES AND SELECTIVE ATTENTION DEFICITS IN ALZHEIMER'S DISEASE
Author(s) -
Luedke Angela,
Garcia Angeles,
HernandezCastillo Carlos,
FernandezRuiz Juan
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.169
Subject(s) - precuneus , stroop effect , default mode network , psychology , neuroscience , middle temporal gyrus , audiology , posterior cingulate , precentral gyrus , middle frontal gyrus , functional magnetic resonance imaging , cognition , medicine , magnetic resonance imaging , radiology
SMC group, A+N showed cortical thinning in the left/right parietal inferior and superior regions (p<.028), temporal middle and superior temporo-lateral gyri (p1⁄4.05), left inferior frontal gyrus (p1⁄4.009), right lateral fusyform gyrus (p<.002), insula and precentral sulcus (p1⁄4.01). SNAP patients compared to SMC exibithed cortical thinning in the left central sulcus (p1⁄4.025), right superior and inferior tempro-lateral (p<.002) and parietal gyri (p1⁄4.04), and precentral sulcus (p1⁄4.011). The direct comparison between A+N and SNAP showed significant cortical thinning only in theA+Ngroup in the right and left lateral fusyform gyrus (p<.039), left occipital middle and lingual gyri (p1⁄4.020 and p1⁄4.007), parietal regions (p<.049) and orbito-lateral sulcus (p1⁄4.041). Both SNAP and A+N groups compared to SMC showed substantial subcortical volume reductions bilaterally in the hippocampus (p<.05), the nucleus accumbens (p<.046), the right pallidum (p<.0401), the left amygdala (p<.005). The direct comparisons between the two patient groups revealed a significant right amygdala atrophy in A+N patients. Conclusions: Our results support the hypothesis that SNAP patients are characterized by a different cortical and subcortical involvement relative to A+N due to different underlying pathologic changes.