IC‐P‐161: THE NATIONAL ALZHEIMER'S COORDINATING CENTER MRI DATABASE | Zendy

Heller Katherine B. | Zendy; DeCarli Charles | Zendy; Beekly Duane | Zendy; Besser Lilah M. | Zendy; Bollenbeck Mark | Zendy; Wu Joylee | Zendy; Carmichael Owen Thomas | Zendy; Phelps Creighton H. | Zendy; Kukull Walter | Zendy

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IC‐P‐161: THE NATIONAL ALZHEIMER'S COORDINATING CENTER MRI DATABASE

Author(s) -

Heller Katherine B.,

DeCarli Charles,

Beekly Duane,

Besser Lilah M.,

Bollenbeck Mark,

Wu Joylee,

Carmichael Owen Thomas,

Phelps Creighton H.,

Kukull Walter

Publication year - 2014

Publication title -

alzheimer's and dementia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.713

H-Index - 118

eISSN - 1552-5279

pISSN - 1552-5260

DOI - 10.1016/j.jalz.2014.05.168

Subject(s) - neuropathology , medicine , magnetic resonance imaging , fluid attenuated inversion recovery , database , neuroimaging , disease , radiology , pathology , computer science , psychiatry

SMC group, A+N showed cortical thinning in the left/right parietal inferior and superior regions (p<.028), temporal middle and superior temporo-lateral gyri (p1⁄4.05), left inferior frontal gyrus (p1⁄4.009), right lateral fusyform gyrus (p<.002), insula and precentral sulcus (p1⁄4.01). SNAP patients compared to SMC exibithed cortical thinning in the left central sulcus (p1⁄4.025), right superior and inferior tempro-lateral (p<.002) and parietal gyri (p1⁄4.04), and precentral sulcus (p1⁄4.011). The direct comparison between A+N and SNAP showed significant cortical thinning only in theA+Ngroup in the right and left lateral fusyform gyrus (p<.039), left occipital middle and lingual gyri (p1⁄4.020 and p1⁄4.007), parietal regions (p<.049) and orbito-lateral sulcus (p1⁄4.041). Both SNAP and A+N groups compared to SMC showed substantial subcortical volume reductions bilaterally in the hippocampus (p<.05), the nucleus accumbens (p<.046), the right pallidum (p<.0401), the left amygdala (p<.005). The direct comparisons between the two patient groups revealed a significant right amygdala atrophy in A+N patients. Conclusions: Our results support the hypothesis that SNAP patients are characterized by a different cortical and subcortical involvement relative to A+N due to different underlying pathologic changes.

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