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P4‐154: CORRELATION BETWEEN CORTICAL THICKNESS MEASUREMENTS FROM MAGNETIC RESONANCE IMAGING AND COGNITIVE PERFORMANCE ON EPISODIC AND SEMANTIC MEMORY TESTS
Author(s) -
Demey Ignacio,
Rojas Galeno,
Somale Veronica,
Ventrice Fernando
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.1671
Subject(s) - parahippocampal gyrus , boston naming test , episodic memory , audiology , dementia , magnetic resonance imaging , psychology , raw score , medicine , recall , semantic memory , correlation , cognition , radiology , temporal lobe , psychiatry , disease , cognitive psychology , raw data , statistics , epilepsy , geometry , mathematics
OBJECTIVE: To draw a correlation between the performance on Episodic Memory (EM) and Semantic Memory (SM) tests and Cortical Thickness (CT) measurements in healthy controls, patients with amnesic Mild Cognitive Impairment (aMCI) of degenerative etiology, and patients with Alzheimer’s disease (AD) dementia. BACKGROUND: CT measurements have been related to cognitive performance, and cortical thinning in regions of interest can be associated to lower scores in neuropsychological tests. EM and SM are different types of declarative, long-term memory, usually involved in AD. DESIGN/METHODS: 14 AD dementia patients (age: (median±SD) 76,29±8,74 years; education: 11,79±4,74 years) 10 aMCI patients (age:78,50±3,53 years; education: 11,40±4,00 years) and 7 healthy controls (age:73,43±8,22 years; education:12,86±5,24 years) were included. Raw scores on the coding and on the 20-minute delayed free-recall on the California Verbal Learning Test (CVLT) were used to measure EM performance, and raw scores on the Boston Naming Test (BNT) and on Semantic Fluency (FS) were used to measure SM performance, respectively. CT was measured with FreeSurfer. Correlations between patients’ raw scores and CT measurements were analyzed with Pearson´s correlation. RESULTS: Raw scores on the coding on the CVLT were positively correlated with left superior frontal gyrus (r:,356;p:,049) and with left parahippocampal gyrus (r:,449;p:,011) CT; raw scores on the 20-minute delayed free-recall on the CVLT with left parahippocampal gyrus (r,470;p:,008) and with circular sulcus of the insula (r:,422;p:,018) CT; raw scores on the BNT with left temporal pole (r:,580;p:,001) and with left inferior temporal sulcus (r:,496;p:,005) CT; and raw scores on FS with left middle temporal gyrus (r:,422; p:,018) and with right cingulate gyrus (r:,521;p,003) CT, among other significant results. CONCLUSIONS: Based on the results obtained in healthy controls, aMCI and AD dementia patients, the performance on EM and SM tests showed significant positive correlations with CT at several regions of interest. Study Supported by: Fundacion INEBA. Disclosure: Dr. Demey has nothing to disclose. Dr. Rojas has nothing to disclose. Dr. Somale has nothing to disclose. Dr. Ventrice has nothing to disclose.