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P4‐143: PROGRESSION OF PRECLINICAL ALZHEIMER'S DISEASE ASSOCIATED WITH AMYLOID PET AND FDG PET IMAGING
Author(s) -
Hatashita Shizuo,
Yamasaki Hidetomo,
Wakebe Daichi
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.1659
Subject(s) - medicine , biomarker , standardized uptake value , imaging biomarker , positron emission tomography , pittsburgh compound b , nuclear medicine , asymptomatic , oncology , cognitive impairment , pathology , disease , magnetic resonance imaging , radiology , biology , biochemistry
functional images and performed the standard procedures (slice-time correction, motion estimation, ICBM152-fMRI nonlinear template coregistration, resampling, band-pass filtering (0.01-0.1Hz), 6mm isotropic Gaussian blurring kernel smoothing). A scrubbing method was used to exclude volumes with excessive motion (frame displacement > 0.5). Next, we performed a seed-based correlation analysis using fMRIStat, followed by a cross-sectional group comparison and longitudinal analysis with 6 months follow-ups after the initial assessment, with multistat, correcting for both age and gender.Results: 36 controls (age 7567), 65Mild Cognitive Impairment (MCI, age 7267) patients and 26 AD patients’ (age 73.267) images qualified for the study. The posterior cingulate cortex (PCC) was the region most affected by metabolic deficits in Alzheimer’s Disease patients (Figure 1a). A group comparison shows that AD patients have decreased connectivity between the PCC and the anterior cingulate cortex, the left superior temporal gyrus, the perirhinal cortex and the right caudate nucleus (Figure 1c). Longitudinally, AD patients and controls do not show meaningful changes 6 months after initial assessment (Figure 1df). Conversely, MCI patients show connectivity disruptions in the right insula and the left parietal-occipital juncture, while also increases in the left temporal gyrus and the fusiform gyrus bilaterally (Figure 1e). Conclusions: Conforming to previous studies, AD patients have significant metabolic defects in the posterior cingulate cortex (PCC). As a result, connections between the PCC and other areas of the brain are significantly disrupted. A 6 months follow-up is not sufficient for capturing network changes in controls or dementia patients; however, changes in large scale connectivity observed here do fit the conceptual framework in which brain networks undergo compensatory changes in MCI patients.