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P4‐139: RESTING STATE FUNCTIONAL CONNECTIVITY OF EXECUTIVE NETWORK PREDICTS THE PERFORMANCE OF COGNITIVE FUNCTION
Author(s) -
Balachandar Rakesh,
Bharath Srikala,
John John P.,
Saini Jitender,
Kumar Keshava,
Joshi Himanshu,
Aiyappan Subramonium,
Sadanand Shilpa,
Sinha Preeti,
Varghese Mathew
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.1655
Subject(s) - resting state fmri , functional magnetic resonance imaging , neurocognitive , verbal fluency test , prefrontal cortex , psychology , executive functions , cognition , neuroscience , brain activity and meditation , neuropsychology , working memory , blood oxygen level dependent , audiology , cognitive psychology , medicine , electroencephalography
atrophy has not been well defined. In order to determine the relationship between Ab and atrophy, we compared the performance of the usual dichotomization of cerebrospinal fluid (CSF) Ab to identify subjects as Ab+ and Abwith a trilinear spline model of CSF Ab. Methods: 183 subjects with mild cognitive impairment and 108 cognitively normal controls with baseline CSF A b and up to 4 years of longitudinal MRI data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) were analyzed using mixed-effects regression. Piecewise-linear splines were used to evaluate the nonlinear nature of the association between A b and regional atrophy and to identify points of acceleration of atrophy with respect to A b. Several parameterizations of A b were compared using likelihood ratio tests. Periods of acceleration of atrophy in which subjects transition fromA b negativity to A b positivity were estimated from the spline models and tested for significance. Results: Spline models resulted in better fits for many temporal and parietal regions compared with the dichotomous models. The trilinear model showed that periods of acceleration of atrophy varied greatly by region with early changes seen in the insula, amygdala, precuneus, hippocampus, and other temporal regions, occurring prior to the clinical threshold for A b positivity.Conclusions: The use of piecewise-linear splines provides an improved model of the nonlinear association between A b and regional atrophy in regions implicated in the progression of Alzheimer’s disease.