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IC‐P‐156: BRAIN STRUCTURAL, FUNCTIONAL, AND COGNITIVE CORRELATES OF RECENT VERSUS REMOTE AUTOBIOGRAPHICAL MEMORIES IN MILD COGNITIVE IMPAIRMENT
Author(s) -
Tomadesso Clémence,
Perrotin Audrey,
Mézenge Florence,
Landeau Brigitte,
Egret Stéphanie,
Sayette Vincent,
Eustache Francis,
Desgranges Béatrice,
Chetelat Gael
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.163
Subject(s) - autobiographical memory , episodic memory , semantic memory , psychology , temporal lobe , cognition , neuroanatomy of memory , posterior cingulate , hippocampus , explicit memory , cognitive psychology , audiology , neuroscience , medicine , epilepsy
article i nfo Deficits in autobiographical memory appear earlier for recent than for remote life periods over the course of Alzheimer3sdisease(AD).Thepresentstudyaimstofurtherourunderstandingof thisgradedeffectbyinvestigat- ing the cognitive and neural substrates of recent versus remote autobiographical memories in patients with amnestic Mild Cognitive Impairment (aMCI) thanks to an autobiographical fluency task. 20 aMCI patients and 25 Healthy elderly Controls (HC) underwent neuropsychological tests assessing remote (20-to-30 years old) and recent (the ten last years) autobiographical memory as well as episodic and semantic memory, executive function and global cognition. All patients also had a structural MRI and an FDG-PET scan. Correlations were assessed between each autobiographical memory score and the other tests as well as grey matter volume and metabolism. Within the aMCI, performances for the remote period correlated with personal semantic memory and episodic memory retrieval whereas performances for the recent period only correlated with episodic mem- ory retrieval. Neuroimaging analyses revealed significant correlations between performances for the remote pe- riod and temporal pole and temporo-parietal cortex volumes and anterior cingulate gyrus metabolism, while performancesfortherecentperiodcorrelatedwithhippocampalvolumeandposteriorcingulate,medialprefron- tal and hippocampus metabolism. The brain regions related with the retrieval of events from the recent period showed greater atrophy/hypometabolisminaMCIpatients comparedtoHCthan those involvedinremote mem- ories.Recallofrecentmemoriesessentiallyreliesonepisodicmemory processesandbrainnetworkwhileremote memories also involve other processes such as semantic memory. This is consistent with the semanticization of