Premium
P4‐111: COMPARISON OF DIAGNOSTIC ACCURACY OF AD AT PATIENTS' FIRST CONTACT BETWEEN VISUAL ASSESSMENT AND AUTOMATED ANALYSIS OF BRAIN PERFUSION SPECT
Author(s) -
Kaneta Tomohiro,
Nakatsuka Masahiro,
Nakamura Kei,
Seki Takashi,
Yamaguchi Satoshi,
Tsuboi Masahiro,
Meguro Kenichi
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.1627
Subject(s) - dementia with lewy bodies , frontotemporal dementia , medicine , dementia , concordance , nuclear medicine , diagnostic accuracy , vascular dementia , radiology , single photon emission computed tomography , disease
Background: Core symptom in Alzheimer’s disease (AD) is a retrograde amnesia, where recent events are often significantly more affected than remote events. The hippocampus which is considered as a crucial neuroanatomical structure for memory consolidation is early impaired in this neurodegenerative disease. In the standard model of consolidation it is assumed that this temporal gradient in memory performance is due to a time-limited role of the hippocampus in memory storage. Remote events become stored in the neocortex and are therefore not affected by the hippocampal damage. The Multiple Trace Theory postulates that remote memories are better protected by a larger number of hippocampal-neocortical memory traces. Own studies of autobiographical memory and memory performance of historical events in AD suggest that not the temporal component but the retrieval frequency is most important for the memory performance. Methods: In 29 healthy controls and 25 patients with ADmemory performance of important historical events of the past 50 years were evaluated with the Historic Events Memory Test. Retrieval frequency was operationalized by a paired comparison analysis. Using voxelbased morphometry it was correlatively evaluated whether frequently recalled memories depend less on hippocampal degeneration than seldomly retrieved memories. Results: While we found a significant correlation between memory performance and hippocampal volume for the seldomly retrieved events in patients with AD we did not show this association for frequently retrieved events. Conclusions: Our findings indicate that more frequently remembered events are more independent of hippocampal structures. Thus, it can be concluded that mental activity protects against the neurodegenerative process of incipient AD.