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P4‐108: APPLYING AUTOMATED MR‐BASED DIAGNOSING IN A MEMORY CLINIC: A PROSPECTIVE STUDY WITH MILD COGNITIVE IMPAIRMENT
Author(s) -
Abdulkadir Ahmed,
Klöppel Stefan,
Peter Jessica,
Ludl Anna,
Maier Sabrina,
Pilatus Anne,
Mader Irina,
Hüll Michael
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.1624
Subject(s) - dementia , neuropsychology , medicine , neuroimaging , cognitive impairment , prospective cohort study , confidence interval , medical physics , cognition , memory clinic , artificial intelligence , psychiatry , computer science , disease
seeds placed in the medial prefrontal cortex (mPFC) and posterior cingulate (PCC). Two sample t-tests were used to compare connectivity across diagnostic groups for each seed. The brain-behaviour relationship with indexes derived from the semantic battery was assessed using simple correlations. Results: Patients showed an extensive semantic memory impairment characterized by decreased performance in category fluency, visual naming, naming from definition, words-association and reading. Compared to healthy elderly, patients showed increased DMN connectivity between the mPFC and the PCC (BA 29/30), and between the PCC and the parahippocampus and anterior hippocampus, (BA 36). Patients showed also a significant negative correlation of mPFC connectivity with parahippocampus and posterior hippocampus (BA 27) and total scores on the visual naming task. Conclusions: Our findings suggest that DMN connectivity alterations may contribute to semantic memory deficits inMCI, specifically in visual naming. An increased DMN connectivity between the mPFC and the PCC, and between the PCC and the parahippocampus and anterior hippocampus, appears to cause relevant disadvantageous reorganization of brain functions in MCI.