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P4‐098: APRAXIA AND ASSOCIATED FEATURES AT PRESENTATION IN DEMENTIA
Author(s) -
Ahmed Samrah,
Baker Ian,
Husain Masud,
Thompson Sian,
Butler Christopher
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.1613
Subject(s) - apraxia , posterior cortical atrophy , dementia , semantic dementia , aphasia , primary progressive aphasia , psychology , audiology , executive dysfunction , differential diagnosis , medicine , frontotemporal dementia , physical medicine and rehabilitation , disease , neuroscience , cognition , pathology , neuropsychology
according to modified Buchmann criteria into frail and non-frail categories. Frailty transitions (progressed, no change, regressed) were assessed. Univariate analyses and multinomial logistic regression was performed. Results: 13 MCI, 51 mild and 10 moderate AD subjects were studied, of which 23.1%, 21.6% and 30% were frail at baseline respectively. 17.6% progressed, 68.9% remained unchanged and 13.5% frailty status regressed at 6 months. This appeared independent of their cognitive subgroups (p1⁄40.52). Significant differences were noted in prevalence of atrial fibrillation (15.4%, 0%,0%), decreased activities (none <20 minutes daily) (78.0%, 19.6%, 60.0%), CMMSE scores (17.2 + 5.5, 20.2 + 4.6, 15.0 + 6.1) between frailty status progressed, no change and regressed states respectively (all p<0.05). Multinomial logistic regression showed only lifestyle activities to contribute significantly to frailty status progression (OR 1.10, 95% CI 0.311.89).Conclusions: This study is the first to show frailty state transitions in 6 months among subjects with cognitive impairment. Contrary to expectations of frailty progression to be most significantly affected with increasing levels of cognitive impairment, the frailty transitions appear independent of stage of cognitive impairment. Lifestyle activities contributed most to frailty transitions, which could potentially serve as a modifiable factor to address physical frailty progression in cognitive impairment.