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P4‐089: SELF‐ AND INFORMANT‐RATED DAILY FUNCTION IS ASSOCIATED WITH AMYLOID AND NEURODEGENERATIVE IMAGING IN COGNITIVELY NORMAL INDIVIDUALS
Author(s) -
Mielke Michelle M.,
Hagen Clint,
Roberts Rosebud O.,
Vemuri Prashanthi,
Machulda Mary M.,
Christianson Teresa,
Pankratz Ver S.,
Knopman David S.,
Lowe Val J.,
Jack Clifford,
Petersen Ronald
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.1604
Subject(s) - neurodegeneration , neuroimaging , dementia , psychology , cognition , clinical dementia rating , odds ratio , alzheimer's disease , logistic regression , medicine , depression (economics) , disease , neuroscience , economics , macroeconomics
Background: The pathophysiology of cognitive impairment in Parkinson’s disease is poorly understood. It is postulated that Alzheimer’s pathology contributes to cognitive impairment in Parkinson’s disease. This study aimed to determine neuroimaging correlates of cognitive impairment in Parkinson’s patients with and without mild cognitive impairment. Methods:A cohort of 97 consenting Parkinson’s disease patients underwent complete physical, neurological, and neuropsychological examinations as part of an imaging study. Hippocampal volumes and volumes of White Matter Hyperintensities (WMH) were derived using an automated program from Magnetic Resonance Images. Multivariable logistic regression models controlling for age and education were used to determine associations with higher WMH and lower hippocampal volumes in Parkinson’s patients with Mild Cognitive Impairment (MCI) and no cognitive impairment (NCI). Results: Of 97 Parkinson’s patients, 71 (73%) had NCI and 26 (27%) had MCI. In multivariate analyses adjusting for age and education, the MOCA (OR 0.44, CI 0.24-0.81), Immediate and Delayed Recall (OR 1.42, CI 1.11-1.81), Color Trails 2 (OR 1.02, CI 1.01-1.04), and Fruit Fluency (OR 0.71, CI 0.53-0.93) were independently associated with hippocampal volumes in Parkinson’s patients with NCI. There were no significant associations between cognitive tests and WMH in either NCI or MCI patients. Conclusions: These findings suggest that cognitive impairment within Parkinson’s patients appear to be associated with hippocampal volume loss. Further studies to investigate the contribution of hippocampal volume to cognitive function in early Parkinson’s disease is warranted.