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P4‐057: OLFACTORY IDENTIFICATION DEFICITS PREDICT THE TRANSITION FROM MCI TO AD IN A MULTI‐ETHNIC COMMUNITY SAMPLE
Author(s) -
Devanand Davangere,
Lee Seonjoo,
Manly Jennifer,
Andrews Howard,
Schupf Nicole,
Brickman Adam M.,
Louis Elan,
Stern Yaakov,
Mayeux Richard
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.1572
Subject(s) - dementia , ethnic group , psychology , audiology , cognition , boston naming test , gerontology , medicine , clinical psychology , developmental psychology , psychiatry , neuropsychology , disease , sociology , anthropology
PET amyloid scanning with 18 F-Fluorobetaben. Compared to those lost to follow-up, participants were healthier, a year younger and more likely to have higher education. Over the 15 years from 1998 to 2013, 8 participants had developed significant cognitive disease (MCI, AD). Only 14 of 125 imaged participants were amyloid positive (18 F-Fluorobetaben suvr>1.4), consistent with the mostly healthy cohort. Those amyloid positive healthy participants recalled fewer words on the word test recall compared to the amyloid negative participants (mean cvlt1⁄49 words Vs mean cvlt1⁄4 12 words) p<0.05 accounting for age, education and presence of APOE34. Conclusions: The Women’s Healthy Ageing Project imaging study is unique in its sample of more than 100 participants imaged with 18 F-Fluorobetaben and 15 years of preceding cognitive tests and more than 20 years of clinical, physical and biomarker information. Given the importance of examining the development of cognitive decline and neurodegeneration with the now known prodrome of several decades, this study database will provide new insights into the early development of disease and in particular midlife risk factors. Data is available via BioGrid Australia. www.biogrid. vic.gov.au.