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P4‐008: APP INTRON 7 POLYMORPHISM AND PLASMA AMYLOID‐BETA PEPTIDE LEVELS CAN PREDICT THE ONSET OF DEMENTIA IN DOWN's SYNDROME
Author(s) -
Somani Alyma A.,
Jones Emma,
Rasmussen Jill,
Ballard Clive G.
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.1522
Subject(s) - pathogenesis , dementia , amyloid beta , medicine , amyloid precursor protein , endocrinology , amyloid (mycology) , intron , alzheimer's disease , biology , gene , disease , genetics , pathology
AD brain. Conclusions: Such miRNA-mRNA regulatory systems mediated by a family of celland/or tissue-enriched circRNAs represent another important layer of genetic/ epigenetic control over gene expression in both brain health anddisease. Deficits in ciRS-7,and other circRNA-mediated ’miRNA sponging systems’ that drive the ambient upregulation of specific inducible miRNAs may help explain not only inflammatory amyloidogenesis, but the widely observed, generalized and progressive down-regulation of targeted gene expression that is characteristic of the sporadic AD brain.