Premium
IC‐P‐146: THE ASSOCIATION BETWEEN CSF AND FDG/PET IMAGING BIOMARKERS OF NEURODEGENERATION IN MILD COGNITIVE IMPAIRMENT
Author(s) -
Trošt Maja,
Tomše Petra,
Rot Uroš,
Grmek Marko,
Jensterle Luka,
Berlot Rok,
Kavcic Voyko,
Kramberger Milica G.,
Pirtošek Zvezdan
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.152
Subject(s) - precuneus , medicine , cognitive impairment , temporal lobe , positron emission tomography , neurodegeneration , montreal cognitive assessment , pathology , psychology , gastroenterology , nuclear medicine , disease , cognition , psychiatry , epilepsy
tangles, neuritic and diffuse plaques.QSMmaps were created with a magnitude-weighted L1-regularization algorithm.The susceptibility maps from all participants were spatially normalized by non-linearly registering the susceptibility maps to a template using the Automated Registration Toolbox. The putamen and caudate were outlined on the template and the outlines were superimposed onto the spatially transformed susceptibility maps. Themedian susceptibility value in each regionwas extracted for each participant. Linear regression was used in each region to investigate the link between susceptibility values and the composite measure of global AD pathology, controlling for age at death, sex, and postmortem interval to imaging. Statistical significance was set at p<0.05. Results: Statistically significant positive correlations were detected between magnetic susceptibility values and the composite measure of global AD pathology in the putamen (p1⁄40.035) and caudate (p1⁄40.021). Conclusions: These findings suggest that magnetic susceptibility values in subcortical gray matter measured with QSM are sensitive to AD pathology. This study provides a strong indication that QSM may play an important role in the development of biomarkers of AD pathology.