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P3‐415: TESTING OF INNATE IMMUNITY STIMULATION VIA TLR9 ON CEREBRAL AMYLOID ANGIOPATHY USING NON‐HUMAN PRIMATES
Author(s) -
Scholtzova Henrieta,
Nehete Pramod N.,
Nehete Bharti P.,
Holmes Andrea,
Spadaccia Meredith,
Sprinzen Lisa M.,
Jamal Mohsin,
Sabado Rachel L.,
Williams Lawrence E.,
Wisniewski Thomas
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.1510
Subject(s) - squirrel monkey , immunology , primate , tlr9 , medicine , cytokine , marmoset , immune system , biology , neuroscience , biochemistry , gene expression , gene , dna methylation , paleontology
and hence safe for brain delivery and also achieved enhanced and precise targeted delivery to amyloid plaque in the brains of AD model rat compared to the unmodifiedNPs and the free drug.When administration of dual ligand conjugated PLGA NPs of BQCA in streptozotocin-induced animals significantly decreased escape latency (Fig 1). Conclusions: A dual-functional drug delivery system was developed to target AD lesions using TGN and QSH appended to the surface of BQCA loaded PLGA NPs and demonstrate might be a valuable targeting system for treatment of AD.