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IC‐P‐144: NEUROPATHOLOGIES LINKED TO BRAIN WHITE MATTER HYPERINTENSITY VOLUME IN OLDER ADULTS: AN EX‐VIVO MRI AND PATHOLOGY INVESTIGATION
Author(s) -
Kotrotsou Aikaterini,
Arfanakis Konstantinos,
Bennett David,
Schneider Julie,
Leurgans Sue
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.150
Subject(s) - hyperintensity , medicine , pathology , fluid attenuated inversion recovery , dementia , ex vivo , white matter , magnetic resonance imaging , atrophy , alzheimer's disease , neuropathology , senile plaques , cohort , nuclear medicine , radiology , disease , in vivo , microbiology and biotechnology , biology
each voxel separately (approach #2) allowed detection of simulated abnormalities more often and in more voxels than controlling for the total volume of WMHs (approach #1) (Figure 1). The difference between approaches decreased for increasing levels of simulated abnormality. Conclusions: In cross-sectional voxel-wise diffusion MRI studies of aging, controlling for the presence of WMHs in each voxel separately instead of the total volume of WMHs, increases sensitivity to low levels of microstructural brain abnormality.