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IC‐P‐140: GLUCOSE METABOLISM IMPACT ON FUNCTIONAL CONNECTIVITY IN ALZHEIMER'S DISEASE
Author(s) -
Wang Seqian,
Carbonell Felix,
Beaudry Thomas,
Mathotaarachchi Sulantha Sanjeewa,
Leuzy Antoine,
Mohades Sara,
Zimmer Eduardo Rigon,
Fonov Vladimir,
Bellec Pierre,
Gauthier Serge,
RosaNeto Pedro
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.146
Subject(s) - alzheimer's disease neuroimaging initiative , posterior cingulate , context (archaeology) , resting state fmri , positron emission tomography , functional magnetic resonance imaging , neuroimaging , medicine , alzheimer's disease , neuroscience , precuneus , disease , psychology , biology , paleontology
associations in the frontal, posterior parietal, occipital and temporal regions. Conclusions: Decreased levels of CSFAb 1-42 and increased [18 F]florbetapir uptake were associated, at follow up, with performance decrements on the ADAS-cog and increased levels of CSF tau. These findings support an association between amyloidosis and neurodegeneration, and suggest that individuals belonging to the progressive discordant group are most at risk for progression to AD dementia.