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P3‐335: COGNITIVE RESERVE AND COGNITIVE FUNCTION: A META‐ANALYSIS
Author(s) -
Opdebeeck Carol,
Martyr Anthony,
Clare Linda
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.1428
Subject(s) - cognitive reserve , cognition , proxy (statistics) , psychology , meta analysis , cognitive decline , dementia , cognitive psychology , medicine , statistics , cognitive impairment , disease , psychiatry , mathematics , pathology
dietary patterns emerged: 1) western-like pattern including potatoes, highfat spreads and dairy products, refined grains, meat, sweets and cookies, beer and spirits; and 2) prudent-like pattern including fruits, vegetables, legumes, cereals, whole grains, rice/pasta, low-fat dairy products, fish, poultry and tea. Data were analyzed using the multilevel Mixed-effects linear regression with adjustment for potential confounders. Results: At baseline, western-like and prudent-like dietary patterns were significantly associated with age, sex, education, physical activity, and supplement intakes. The meanMMSE scorewas 29.260.8 at baseline and 27.962.7 at 6year follow-up. In multi-adjusted Mixed-effects model, higher adherence to western-like dietary pattern was significantly associated with global cognitive decline (b: -0.06; 95% CI: -0.09, -0.03, p1⁄4<.001), but higher adherence to prudent-like dietary pattern was inversely related to cognitive decline (b: 0.05; 95% CI: 0.02, 0.08, p1⁄4.001). The coefficients were adjusted for total energy intake, demographics, physical activity, smoking, anthropometrics, chronic conditions, APOE4 allele, and vitamin or mineral supplement intakes. Conclusions: Western-like dietary pattern is associated with an increased risk of cognitive decline, whereas prudentlike dietary pattern seems to play a protective role in cognitive aging among dementia-free older adults.