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P3‐251: DIAGNOSTIC ACCURACY OF THE OPERATIONAL CRITERIA FOR THE DIAGNOSIS OF ALZHEIMER'S DISEASE (BEIJING VERSION)
Author(s) -
Tian Jinzhou,
Tian Jinzhou,
Shi Jing,
Wei Mingqing
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.1343
Subject(s) - medicine , beijing , dementia , disease , diagnostic accuracy , chinese population , predictive value , population , clinical diagnosis , pediatrics , clinical practice , memory clinic , gerontology , china , physical therapy , environmental health , biochemistry , chemistry , political science , law , genotype , gene
Background: Dementia is becoming a major health problem among older adult. Although the NINCDSADRDA criteria showed high sensitivity in diagnosing Alzheimer’s disease (AD), there was over 93.1% of dementia cases in China go undetected, which was mainly due to lack of operational diagnosis criteria ofADbased on spokenChinese population. Theoperational criteria for the diagnosis of AD (Beijing version) (OCDAD) have been developed in an attempt to fulfill to this need. This study aimed to determine the diagnostic accuracy of the OCDAD. Methods: Total 676 subjects 50 to 85 years old were enrolled in six memory clinics in China. Subjects were used the NINCDS/ADRDA for a clinical diagnosis of probable or possible AD by one clinician. And then there were accessed by the OCDAD by another clinician. There was no contact or discussion about any of the cases between the two clinicians. Diagnostic accuracy was assessed by comparing the two criteria. Results: Total 167 cases met NINCDS-ADRDA criteria for a clinical diagnosis of probable or possible AD. 197 cases met the OCDAD. Compared to the NINDCS-ADRDA, the OCDAD showed high diagnostic accuracy is 95.85%, also showed high sensitivity and specificity for detecting AD 83.23% and 88.61%, the positive predictive value (PPV) is 72.56%, the negative predictive value (NPV) is 94.15%. Conclusions: The OCDAD was developed based on Chinese population, and showed high diagnostic accuracy for AD, it could be easily implemented in a clinician’s practice, and would be used as an operational criteria for diagnosis AD in China.