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P3‐219: MORPHOLOGICAL AND FUNCTIONAL CONNECTIVITY CHANGE OF BASAL GANGLIA IN AMNESTIC MILD COGNITIVE IMPAIRMENT
Author(s) -
Lee Chang Uk,
Hahn Changtae,
Lim Hyun Kook
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.1310
Subject(s) - putamen , basal ganglia , neuroscience , psychology , middle frontal gyrus , precuneus , gyrus , caudate nucleus , functional magnetic resonance imaging , anatomy , medicine , central nervous system
Background: Although the basal ganglia (BG) are involved in the earlier pathological changes of the Alzheimer’s disease, little is known about the functional and structural changes of BG in the amnestic mild cognitive impairment (aMCI). The aim of this study is to explore the structural, functional changes of BG and their inter-dependencies in aMCI.Methods:A total of 50 aMCI subjects and 50 group matched healthy controls underwent the structural and resting state functional magnetic resonance imaging (MRI). We measured the volume and deformations of the BG of subjects. The functional connecitivities (FC) of the BG were also investigated with the caudate, the putamen and the pallidum seeds. In addition, we also tried to explore the distinctive relationships between the morphological changes and functional network changes using graph theory analysis. Results: We found that deformations of the ventrocaudal part of the putamen and pallidum, and rostal part of the caudate were more prominent in the aMCI group compared with the controls. The caudate seed revealed decreased FC in the frontal region including superior medial and orbital in the aMCI group relative to the controls. On the other hand, the putamen and the pallidum seed revealed the increased FC in the middle and superior orbital frontal and suprmargial gyrus the anterior cingulate, precuneus, angular gyrus and insular in the aMCI group compared to the controls. The volumes of the basal ganglia of the aMCI group were negatively correlated with the nodal betweenness based on the FC of each basal ganglia node. Conclusions: As BG were connected to the important functional hub structures of the brain, structural and functional alterations of these structures in the aMCI subjects might be related to the serious cognitive and behavioral impairment in aMCI subjects. However, the further longitudinal study might be needed to confirm these hypotheses.