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P3‐197: AGE‐RELATED FUNCTIONAL CONNECTIVITY CHANGES: VARIATIONS IN MAGNITUDE AND SHIFTS FROM NEGATIVE TO POSITIVE CORRELATIONS
Author(s) -
Ferreira Luiz Kobuti,
Brocanello Regina Ana Carolina,
Kovacevic Natasa,
Godoi Carneiro Camila,
da Graça Morais Martin Maria,
Amaro Edson,
McIntosh Anthony Randal,
Busatto Geraldo F.
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.1287
Subject(s) - magnitude (astronomy) , correlation , negative correlation , partial correlation , psychology , mathematics , medicine , physics , geometry , astronomy
matter. Models were adjusted for age, sex, scan interval, intracranial volume, white matter atrophy and white matter lesion load. Additionally, influence of cardiovascular risk factors on DTI changes was studied. Results: Over 2 years of follow-up, global FA decreased by 0.0038 (p<10 -6), while MD increased by 9.0 x 10 -6 mm 2/s (p<10 -6) reflecting loss of white matter microstructure. Voxelwise analyses showed that FA decreased widespread in the brain, except in the sensorimotor pathway, where an increase in FA was found (see Figure). MD values increased throughout the white matter. In addition to the change over time, we found more pronounced white matter diffusion changes in older persons. Cardiovascular risk factors were not associated with changes in tissue microstructure. Conclusions: In a large population of non-demented elderly, we found longitudinal changes in FA and MD, reflecting loss of white matter microstructure over time. Our results are suggestive of widespread normal appearing white matter changes in aging, with relative sparing of sensorimotor fibres. Furthermore, we found that white matter degeneration is more pronounced with higher age, but not driven by specific cardiovascular risk factors.