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P3‐187: CEREBRAL CORTICAL MICROINFARCTS ON 3TESLA MRI IN AN ASIAN MEMORY‐CLINIC POPULATION
Author(s) -
Veluw Susanne J.,
Hilal Saima,
Ikram Mohammad Kamran,
Biessels Geert Jan,
Chen Christopher
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.1277
Subject(s) - memory clinic , medicine , hyperintensity , dementia , population , fluid attenuated inversion recovery , statistical parametric mapping , nuclear medicine , magnetic resonance imaging , psychology , pathology , radiology , disease , environmental health
association can also be observed in Amyloid accumulation with the disease severity. Hypometabolism ([18F]FDG SUVR) shows an opposite variation (increase) when comparing the baseline and follow-up regional associations but decreases with disease severity. However, the regions that shows association in their rate of Amyloid accumulation and hypometabolism decrease with the disease severity [Figure 1]. Conclusions: Regional Association Maps capture the dynamic architecture of amyloid and hypometabolism propagation, occurring as the disease progresses. Regional associations decline for Amyloid accumulation as a function of the disease progression can be attributed to the non-linear rate of amyloidosis (reaching a plateau). This behavior is also supported by the reduction in regional associations for the rate of amyloid accumulation with the increase in disease severity.