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P3‐169: NEGATIVE IMPACT OF DEPRESSIVE SYMPTOMS ON FUNCTIONAL STATUS IN PATIENTS WITH MILD COGNITIVE IMPAIRMENT
Author(s) -
Won Wangyoun,
Hahn Changtae
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.1259
Subject(s) - geriatric depression scale , depression (economics) , dementia , activities of daily living , clinical dementia rating , analysis of variance , correlation , medicine , rating scale , verbal fluency test , cognition , cognitive impairment , psychology , depressive symptoms , physical therapy , neuropsychology , psychiatry , disease , developmental psychology , economics , macroeconomics , geometry , mathematics
Background: Depression is a common co-morbid disorder in patients with mild cognitive impairment (MCI), however, not all patients with MCI exhibit depressive symptoms. This study aimed to investigate the effect of depression on cognitive and functional decline in MCI.Methods: Two hundred and eighty one patients with MCI (MCI) defined by 0.5 score on Clinical Dementia Rating were included in the study. Patients were divided into three groups based on their Geriatric Depression Scale (GDS) scores: MCI without depression (GDS<10, n1⁄450), MCI with mild depression (GDS10w19, n1⁄4120), and MCI with severe depression (GDS>20, n1⁄4111). Cognitive function tests (cognitive domains in CERAD-K including letter fluency, trail making test-A and B, and verbal learning test) and Blessed Dementia Scale-Activities of Daily Living (BDS-ADL) were measured. Group differences were analyzed using an analysis of variance (ANOVA). Correlation between GDS scores and BDS-ADL were analyzed. Results: An ANOVA test showed that activities of daily living differed significantly across groups (F(2, 276) 1⁄4 13.53, p<0.001). Posthoc analysis showed MCI with severe depression had a significantly higher mean BDS-ADL score compared with both MCI without depression and MCI with mild depression (both, p<0.001). Correlation analysis showed significant positive correlation between GDS and BDS-ADL (r1⁄40.366, p<0.001). However, mean scores of cognitive function tests were not different among three groups. Conclusions: The present study suggests that co-morbid depressive symptoms may have negative impact on functional status in patients with MCI. This may further suggest the importance of evaluation and treatment of depressive symptoms in patients with MCI.