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P3‐166: BASELINE DEPRESSIVE SYMPTOMS ARE PREDICTIVE OF PROGRESSION TO CLINICAL DEMENTIA AT 5 YEARS: A COMMUNITY‐BASED STUDY IN CHINESE OLDER ADULTS (HONG KONG MEMORY AND AGEING PROSPECTIVE STUDY, HK‐MAPS)
Author(s) -
Wong Candy,
Lam Linda C.,
Lo Heidi,
Fung Ada
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.1256
Subject(s) - dementia , depression (economics) , cognition , medicine , clinical dementia rating , gerontology , geriatric depression scale , neuropsychology , logistic regression , recall , cognitive decline , population , psychology , clinical psychology , depressive symptoms , psychiatry , cognitive impairment , disease , economics , cognitive psychology , macroeconomics , environmental health
0.8%), had depression (47.4% versus 29.6%), experienced hallucinations (21.8% versus 0.5%), had REM sleep behavior disorder (18.1% versus 0.6%), and had earlier cognitive decline onset (mean: 66.1 years vs 72.5 years old). In multivariable analysis, MCI-PD subjects performed significantly better than MCI-AD subjects on the MMSE total, both UDS memory tests, all three UDS language tests, and one of the attention tests. There were no significant differences when comparing scores on the MMSE pentagon (visuospatial) test, the second attention test, or the three executive function tests.Conclusions:MCI-PD and MCI-AD subjects differed on multiple demographic and clinical characteristics. MCI-PD subjects scored better on the UDS measures of verbal learning, semantic fluency, and naming, and there were no significant differences in the groups on UDS measures of visuospatial ability, executive function, and processing speed. The UDS sample of MCI-PD subjects provides an opportunity for future study of multiple domain, amnestic MCI, a less common presentation of MCI-PD.