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IC‐P‐119: MICROSTRUCTURAL WHITE MATTER CHANGES UNDERLYING COGNITIVE IMPAIRMENTS IN AMYOTROPHIC LATERAL SCLEROSIS: AN IN VIVO STUDY USING DTI
Author(s) -
Kasper Elisabeth,
Schuster Christina,
Machts Judith,
Bittner Daniel,
Kaufmann Joern,
Vielhaber Stefan,
Benecke Reiner,
Teipel Stefan,
Prudlo Johannes
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.125
Subject(s) - fractional anisotropy , white matter , diffusion mri , amyotrophic lateral sclerosis , psychology , neuropsychology , neuroscience , cognition , audiology , physical medicine and rehabilitation , medicine , magnetic resonance imaging , pathology , disease , radiology
greater hippocampal activation. Conclusions: MCI patients with evidence of elevated cortical amyloid-b deposition are more likely to demonstrate hippocampal hyperactivation, faster rate of hippocampal atrophy and clinical progression. Amyloid deposition and hippocampal hyperactivity both contribute to hippocampal atrophy. This is consistent with the hypothesis that amyloid accumulation may contribute to excitotoxicity with initial abnormal increases in neuronal activity and eventual neuronal loss over the course of MCI