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P3‐136: LOW CARDIAC INDEX IS ASSOCIATED WITH INCIDENT DEMENTIA AND ALZHEIMER'S DISEASE: THE FRAMINGHAM HEART STUDY
Author(s) -
Jefferson Angela L.,
Beiser Alexa,
Himali Jayandra,
Seshadri Sudha,
O'Donnell Christopher J.,
Manning Warren,
Wolf Philip,
Au Rhoda,
Benjamin Emelia
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.1225
Subject(s) - medicine , dementia , cardiology , atrial fibrillation , framingham heart study , hazard ratio , framingham risk score , diabetes mellitus , cohort , proportional hazards model , disease , endocrinology , confidence interval
hypersensitivity for neuroleptic drugs. Moreover, appropriate treatment of symptoms can improve quality of life considerably for both the individual with LBD and their caregivers. This study aimed to investigate the prevalence of possible LBD and neuroleptic treatment in elderly care recipients in nursing homes.Methods: Information regarding prevalence of symptoms of LBD and concurrent medication in 644 elderly living in nursing homes in Malm€o, Sweden during the time period 2012-13 was collected. We used a questionnaire, medical journals and interviewed the nursing staff. In the questionnaire, symptoms representing the 4 LBD main characteristics were noted as present/absent; Parkinsonism, visual hallucinations, excessive daytime sleepiness, acting out dreams. Neuroleptic treatment was also noted as present or not, as well as the type of drug.Results: In total, 27.3% had 2 of 4 LBD symptoms. 7.1% had 3, and 3.0% had 4 of these symptoms. Visual hallucinations were observed in 20% and REM sleep behaviour disorder in 9% of the patients. Neuroleptic treatment increased significantly (p<0.001) with increasing number of LBD symptoms. In individuals with no symptoms 12.8%, 1 symptom 24.7%, 2 symptoms 26.9%, 3 symptoms 28.9%, and 4 symptoms 42.1% were treated with neuroleptics. Nine percent of the neuroleptics prescribed were of acceptable type (klozapin, quetiapin). Conclusions: Symptoms consistent with LBD are common in elderly in nursing homes. Despite the recommendations of avoiding neuroleptic treatment this was a common finding among the studied individuals. To minimise inappropriate medical treatment recognizing symptoms of LBD are important for general practitioners.