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P3‐106: GENETIC ANALYSIS OF THE STEROIDOGENESIS PATHWAY: ASSOCIATIONS WITH ALZHEIMER'S DISEASE RISK AND RELATED PHENOTYPES
Author(s) -
Wilson Andrea C.,
Garin Sara,
Sandra Porter Tenielle Louise,
Verdile Giuseppe,
Groth David M.,
Villemagne Victor L.,
Ames David,
Bush Ashley I.,
Ellis Kathryn A.,
Macaulay Lance,
Masters Colin L.,
RaineySmith Stephanie Ruth,
Rembach Alan,
Rowe Christopher,
Taddei Kevin,
Martins Ralph N.,
Laws Simon Matthew
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.1195
Subject(s) - medicine , endocrinology , testosterone (patch) , neurodegeneration , hormone , alzheimer's disease neuroimaging initiative , biology , alzheimer's disease , disease
proteins was quantitated using a l abel-free protein quantification method, and these were competed with the concentrations of A b42, pTau181, and tTau. Results: The MMSE score in AD patients was 21.3 6 4.9, and the average CDR scores were 0.86 0.3. All of the CSF samples were sufficient to establish the diagnostic cut-off value of the Ab42/pTau181 and Ab42/ tTau ratios in our laboratory.Fifteen of the 724 protein samples demonstrated a significant correlation with at least one of the AD biomarkers (p < 0.05). Seven of these proteins were previously identified as AD biomarkers, whereas eight were newly found. T he direction of change in the levels of Ab42 was found to be opposite to those of the levels of the Tau proteins in all analytes. Regarding the Ab42 levels, four proteins revealed a significant correlation. Another four proteins demonstrated a significant correlation with both pTau181 and tTau concentrations. We found three proteins to have a significant relationship only with pTau181, whereas two proteins showed a significant correlation only with tTau levels. Interestingly, t here were no analytes that demonstrated a correlation with both Ab42 and Tau proteins simultaneously. The remaining proteins showed a distinct correlation with the combined ratio of Ab42/ pTau181 or Ab42/tTau; however, the relationship with the individual concentrations was statistically negligible. Conclusions: Through our work, we identified new candidate CSF biomarkers of AD. Considering their biological roles, these candidate markers are suggested to be intimately related to AD pathophysiology. Further investigations are needed to identify their values as surrogate biomarkers or therapeutic targets in AD.