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P3‐100: HETEROGENEITY OF CEREBROSPINAL FLUID BIOMARKER LEVELS IN COGNITIVELY NORMAL INDIVIDUALS WITH A FAMILY HISTORY OF ALZHEIMER'S DISEASE
Author(s) -
Dowling N.M.,
Johnson Sterling,
Zetterberg Henrik,
Bendlin Barbara B.,
Gleason Carey Elizabeth,
Carlsson Cynthia,
Sager Mark A.
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.1188
Subject(s) - biomarker , apolipoprotein e , disease , family history , alzheimer's disease neuroimaging initiative , cerebrospinal fluid , cohort , oncology , pathological , medicine , dementia , alzheimer's disease , psychology , biology , genetics
revealed no differences across groups. The 3 groups performed the same on ITC and ERP measures in the fN400 region and time window. Analysis of recollection revealed significant ITC phase locking to stimulus for mid-aged adults but not for older-adults or patients. ERP analysis revealed older-adults had significantly higher amplitude than the mid-aged and patient groups. Conclusions: Present findings for familiarity indicate no effects with age or pathological change. Findings for recollection show older-adults differ in ERP amplitude compared to the mid-aged and patient groups; while mid-aged differ in ITC compared to older-adults and patients. These findings support the notion that recollection, which requires more integration of information than familiarity, is susceptible to changes in age and pathology. The difference in ITC suggests that while older adults are still able to complete the task, they do so by means than their younger counterparts. One potential explanation for increased amplitude of older-adults, despite their lack of coherence, is the explicit memory task. Olderadults may have implemented a strategy to recruit more resources and complete the task successfully.