Premium
P3‐040: ALTERED INTRINSIC PROPERTIES OF HIPPOCAMPAL PUTATIVE O‐LM INTERNEURONES IN TRANSGENIC MOUSE MODELS OF AMYLOIDOPATHY
Author(s) -
Tamagnini Francesco,
Brown Jon T.,
Randall Andrew D.
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.1127
Subject(s) - hippocampal formation , neuroscience , patch clamp , genetically modified mouse , biology , gabaergic , hippocampus , biocytin , subiculum , depolarization , electrophysiology , transgene , membrane potential , chemistry , biophysics , gene , genetics , inhibitory postsynaptic potential , dentate gyrus
analysis of the Tg2576 dentate gyrus proteome and transcriptome that is induced in response to cognitive-enhancing treatment with RSG that led us to discover that the PPARg and ERK/CREB/CBP signaling axes converge to enhance cognition. We found that these key integrators of cognitive performance in the Tg2576 model were central nodes within the GWAS LOAD loci network. Conclusions: These findings suggest the intriguing possibility that these GWAS LOAD loci may represent a functionally interrelated network with the PPARg and ERK/CREB/ CBP signaling axes. The molecular determinants of the convergence of these pathways may represent new targets for therapeutic intervention in cognitive enhancement in AD.