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P3‐034: INSULIN RECEPTORS IN INTACT HIPPOCAMPUS AND HIPPOCAMPAL CULTURED CELLS FUNCTION DOWNSTREAM OF SRC‐FAMILY KINASES TO PROTECT NEURONS AGAINST EXCITOTOXIC GLUTAMATE‐INDUCED CELL DEATH
Author(s) -
Goustin Anton Scott,
Kurkinen Markku T.,
Sanderson Thomas H.,
Hüttemann Maik
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.1121
Subject(s) - insulin receptor , biology , autophosphorylation , microbiology and biotechnology , proto oncogene tyrosine protein kinase src , insulin like growth factor 1 receptor , receptor tyrosine kinase , insulin , receptor , phosphorylation , biochemistry , endocrinology , protein kinase a , insulin resistance , growth factor
to evaluate 5-HT and 5-HIAA breakdown metabolite were performed. Results: 5-HT1B, p11, and SERT protein and gene expression were downregulated in APPswe Sh-SY5Y (P<0.001 and <0, 0001 respectively), and 5-HT production was reduced and 5-HIAA production increased. Similarly, in the Tg2576 mice, hippocampus analysis showed lower levels of 5HT1B, SERT, and p11 (P<0.001). Conclusions: These data collectively show that the 5HT1B receptor and related systems are downregulated in AD. Exploring the behavioral consequences of these changes is warranted.