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IC‐P‐106: LONGITUDINAL RATES OF ATROPHY IN FAMILIAL ALZHEIMER'S DISEASE
Author(s) -
Cash David M.,
Kinnunen Kirsi Maria,
Leung Kelvin K.,
Ahsan Laila,
Cardoso Jorge,
Modat Marc,
Nicholas Jennifer,
Malone Ian,
Benzinger Tammie,
Jack Clifford R.,
Thompson Paul,
Saykin Andrew J.,
Sperling Reisa R.,
Villemagne Victor,
Weiner Michael,
Marcus Daniel,
Bateman Randall,
Morris John,
Rossor Martin,
Ourselin Sebastien,
Fox Nick
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.112
Subject(s) - atrophy , clinical dementia rating , medicine , alzheimer's disease , dementia , cardiology , pathology , disease
profile in SCD individuals and to assess the influence of amyloid deposition. Methods: A total of 54 elderly without objective cognitive deficits were included in the study, on which 15 were recruited from a memory clinic (SCDgroup), and 39 age-, education-, sex-, andMMSE-matchedwere elderly from the general population (control group). All individuals underwent neuropsychological assessment, structural-MRI and amyloid Florbetapir-PET. Between-group voxel-wise comparisons were done on neuroimaging data (p<.005, uncorrected).Results: Significant gray matter atrophy in the hippocampal region was found in the SCD group compared to controls. There was no significant difference in the proportion of amyloid-positive individuals between the two groups. To directly test the influence of amyloid deposition on hippocampal atrophy, group comparison analyses of graymatter volumewere recomputed i) removing the 2 amyloid-positive SCD individuals, ii) adding amyloid deposition values (SUVr) as a covariate. In both conditions, the results remained unchanged, i.e SCD showed significant hippocampal atrophy. Moreover, this hippocampal atrophy correlatedwith episodic memory decline in the SCD, even after controlling for amyloid deposition. Conclusions: Our findings showed that healthy elderly individuals with SCD have significant brain atrophy in the hippocampal region, similar to that observed in AD, and that correlated with decrease episodic memory performance. Importantly, this memory-related hippocampal atrophy in individuals with increased risk for AD seems to be independent from the presence of amyloid deposition as measured with Florbetapir-PET. These results suggest that the AD-like atrophy in SCD is not (directly and/or only) due to amyloid deposition but may involve other neuropathological processes.