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P2‐389: EMPLOYING LYMPHOCYTE PROLIFERATION AS A MEANS TO ASSESS CELL CYCLE DYSREGULATION IN COGNITIVELY IMPAIRED SUBJECTS: CLINICAL PERFORMANCE OF THE LYMPRO ASSAY
Author(s) -
Commissiong Gerald
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.1069
Subject(s) - stimulation , biomarker , peripheral blood mononuclear cell , disease , psychology , medicine , lymphocyte , oncology , audiology , biology , in vitro , biochemistry
table. Conclusions: This pilot validates a sequence enabling recruitment of qualified cognitively normal pre Alzheimer volunteers. It shows mailing by age and ZIP code is an effectiveway to recruit, the usefulness of the telephone CDR and eligibility screen, the accuracy of the TAPA and the importance of a clinical evaluation and cardio respiratory stress test. Reading florbetapir PET visually is accurate as an inclusion criteria. The toning/stretching protocol does not increase the number of steps but the aerobic intervention does. In total, an aerobic exercise study in pre AD is feasible.