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IC‐P‐091: ANALYSIS OF CEREBRAL LOBAR MICROBLEEDS AND DECREASED CEREBRAL BLOOD FLOW IN A MEMORY CLINIC SETTING
Author(s) -
Doi Hikaru,
Inamizu Saeko,
Saito BanYu,
Murai Hiroyuki,
Araki Takehisa,
Kira JunIchi
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.096
Subject(s) - cerebral blood flow , occipital lobe , medicine , memory clinic , temporal lobe , cardiology , frontal lobe , parietal lobe , cognitive impairment , disease , radiology , epilepsy , psychiatry
gene modulation of the ApoE protein-PIB association for CLU, PICALM, ABCA7, BIN1 and MS4A6A. Plasma ApoE showed a significant association with PIB SUVR CerebellarGM in CD2AP rs9349407 minor allele non-carriers (left p corrected 1⁄40.003, right p corrected 1⁄40.004) and CR1 rs3818361 minor allele non-carriers (left p corrected 1⁄40.008, right p corrected 1⁄40.01) but not in carriers (see Figure). Plasma ApoE showed a significant association with PIB SUVR in BIN1 rs744373 minor allele carriers (left p corrected 1⁄40.006, right p corrected 1⁄40.01) but not in nocarriers (see Figure). In CD33 rs3826656 minor allele carriers and noncarriers showed dramatically different pattern of associations with carriers showing a posterior predominant association and non-carriers an anterior predominant association (see Figure). We did not find direct associations between CD2AP rs9349407, CR1 rs3818361, CD33 rs3826656 and BIN1 rs744373 and PIB binding. Conclusions: Our data show that CD2AP rs9349407, CR1 rs3818361, CD33 rs3826656 and BIN1 rs744373 genotypes modulate the association between plasma ApoE protein and brain amyloidosis. These findings imply an interaction between these genotypes and the ApoE protein disease-associated pathways.