Premium
IC‐P‐086: IMPACT OF MOTION ON RESTING‐STATE FMRI CONNECTIVITY IN HEALTHY AGING AND ALZHEIMER'S DISEASE, AND POSSIBLE REMEDIES
Author(s) -
Dansereau Christian,
Orban Pierre,
Bellec Pierre
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.091
Subject(s) - resting state fmri , audiology , medicine , psychology , physical medicine and rehabilitation , neuroscience
displayed at p<0.05 (FWE-corrected). Results: At CDR 0.5, the different AD variants showed relatively distinct patterns of atrophy (see Figure 1). EOAD patients mainly had medial temporal lobe involvement, while lvPPA and PCA were affected most in left temporoparietal regions and right visual association cortex, respectively. At CDR 1, these atrophy patterns extended into the temporo-parietal cortex in EOAD, left anterior lateral temporal regions in lvPPA and the precuneus in PCA. The different variants converged at this stage in lateral temporoparietal cortex, as well as in the medial temporal lobes. Conclusions: Our crosssectional results indicate that brain atrophy is syndromespecific in early disease stages, and converges in temporoparietal cortex and medial temporal lobes as the disease progresses. These findings provide insight into mechanisms that drive heterogeneity in AD, and have implications for early detection of atypical (or non-amnestic) AD variants using MRI. CDR 1⁄4 clinical dementia rating, AD 1⁄4 Alzheimer’s disease, PPA 1⁄4 Primary progressive aphasia, TIV 1⁄4 Total intracranial volume.