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IC‐P‐085: COMPARING ATROPHY PATTERNS IN EARLY CLINICAL STAGES ACROSS DISTINCT PHENOTYPES OF ALZHEIMER'S DISEASE
Author(s) -
Ossenkoppele Rik,
CohnSheehy Brendan I.,
Pijnenburg Yolande,
Seeley William,
Berckel Bart,
Miller Bruce,
Lehmann Manja,
GornoTempini MariaLuisa,
Kramer Joel H.,
Flier Wiesje M.,
Rosen Howard,
Scheltens Philip,
Jagust William,
Barkhof Frederik,
Rabinovici Gil Dan
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.090
Subject(s) - clinical dementia rating , early onset alzheimer's disease , atrophy , temporal lobe , voxel based morphometry , primary progressive aphasia , dementia , posterior cortical atrophy , psychology , alzheimer's disease , neuroscience , precuneus , voxel , entorhinal cortex , pathology , audiology , disease , white matter , frontotemporal dementia , medicine , cognition , magnetic resonance imaging , hippocampus , epilepsy , radiology
Figure 1. A. Scale 40 was chosen for further characterization because it showed an appreciable amount of discoveries (around 5% of the connections were significantly different between groups) in all 3 contrasts (MCI-ECN, DAT-ECN and DAT-MCI). B. Discovery percentage maps show, for each contrast separately, the brain networks with the largest effects (above 20% of significant difference in their associated connections for some networks). Across contrasts, 9 networks were identified as showing the largest effects, in the mesolimbic and default-mode networks as well as in the thalamus and cerebellum crus II. C. Effect maps reveal, for each contrast and 4 selected networks, the nature of the change in functional connectivity (t-test maps of significant differences after FDR correction q<0.1).