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IC‐P‐077: LOBAR MICROBLEEDS PREDICT STROKE IN PATIENTS WITH ALZHEIMER'S DISEASE: THE MISTRAL STUDY
Author(s) -
Benedictus Marije Renske,
Cornelis Goos Jeroen Dirk,
Prins Niels,
Scheltens Philip,
Barkhof Frederik,
Flier Wiesje M.
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.082
Subject(s) - medicine , stroke (engine) , dementia , hazard ratio , proportional hazards model , cause of death , cohort , cardiology , antithrombotic , cerebral amyloid angiopathy , intracerebral hemorrhage , disease , pediatrics , confidence interval , subarachnoid hemorrhage , mechanical engineering , engineering
and sex adjusted models (Table 1; model 1). Adjustment for MTA did not change these result (model 2). Microbleeds and lacunes were no predictors. When clinical progression was restricted to MCI or non-AD dementia, results remained largely unaltered. When clinical progression was restricted to MCI or dementia due to AD, effect estimates remained comparable, but significance was lost. Conclusions: Half of the patients with subjective cognitive complaints have SVD on MRI. In these patients, WMH increase the risk of clinical progression to MCI and dementia.