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IC‐P‐069: ITALIAN NETWORK FOR AUTOSOMAL DOMINANT ALZHEIMER'S DISEASE AND FRONTOTEMPORAL LOBAR DEGENERATION (ITALIANDIAFN)
Author(s) -
Bocchetta Martina,
Pievani Michela,
Babiloni Claudio,
Bruni Amalia C.,
Scarpini Elio,
Sorbi Sandro,
Tagliavini Fabrizio,
Padovani Alessandro,
Benussi Luisa,
Bernardi Livia,
Binetti Giuliano,
Borroni Barbara,
Di Fede Giuseppe,
Di Maria Emilio,
Fostinelli Silvia,
Galimberti Daniela,
Gennarelli Massimo,
Ghidoni Roberta,
Marzano Nicola,
Mega Anna,
Nacmias Benedetta,
Piaceri Irene,
Porteri Corinna,
Rossi Giacomina,
Suardi Silvia,
Vecchio Fabrizio,
Frisoni Giovanni B.
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.074
Subject(s) - frontotemporal lobar degeneration , genetic counseling , geneticist , frontotemporal dementia , medicine , disease , genetic testing , neuroimaging , neuropsychology , psychology , dementia , psychiatry , bioinformatics , cognition , pathology , genetics , biology
sequence. Cardiac Gating was applied with effective TR of 24 R-R intervals. Diffusion datasets were corrected for motion and eddy current distortions (Smith et al., 2004) and then processed with a Spherical Deconvolution algorithm based on a damped version of the Richardson-Lucy algorithm (Dell’acqua et al., 2010, Dell’Acqua et al., 2013). Tractography was performed following the method described in (Catani et al., 2012). We dissected fiftyfive frontal tracts including U-shaped fibers. For each dissection FA (Basser and Pierpaoli, 1996) and hindrance modulated oriented anisotropy (HMOA) (Dell’Acqua et al., 2013) were extracted as an indirect measure of the tract integrity and correlated with the age of the participants regressing out the level of education. P values are presented after false discovery rate (FDR) correction for multiple comparisons (* p < 0.05 ; ** p < 0.01 ; *** p < 0.001). Results: Aging was significantly associated with a decrease of FA (r1⁄4 0.501*) and OA (r1⁄4 0.508**) in the frontal projections of the corpus callosum. Aging was also associated with a decrease of OA in the right frontal lobe including the SLF I (r 1⁄4 0.401**) and SLF III (r 1⁄4 0.576***) branches of the superior longitudinal fasciculus, inferior fronto-occipital fasciculus (r 1⁄4 0.331*), fronto-thalamic projections (r 1⁄4 0.515***). In the left hemisphere, OA measure also decreased with aging for the frontal inferior longitudinal fasciculus (r1⁄4 0.542***) and the frontal orbito-polar tract (r 1⁄4 0.542***). Results are summarized in Figure 1. Conclusions: We confirmed preliminary evidences reporting reduced integrity in the frontal portion of the corpus callosum associated with aging (Lebel et al., 2010). This commissural decline may explain the increased reaction times associated with aging reported in tasks requiring interhemispheric transfer (Reuter-Lorenz and Stanczak, 2000). Our results also suggest for the first time that aging alters significantly other tracts in the right hemisphere which brings up interesting pathophysiological hypotheses for ageing decline in visuospatial and verbal working memory, memory encoding and retrieval, reward-based associative learning that can be tested in the elderly (Cabeza and Dennis, 2012).