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IC‐P‐067: ADVANCED DIFFUSION WEIGHTING IMAGING (DWI) TRACTOGRAPHY OF THE LIMBIC SYSTEM: NOVEL BIOMARKERS OF NEURODEGENERATIVE CHANGES DURING PROGRESSION/CONVERSION FROM COGNITIVE NORMALITY TO AD DEMENTIA
Author(s) -
Thiebaut de Schotten Michel,
Bakardjian Hovagim,
Lista Simone,
Teipel Stefan,
Dyrba Martin,
Filippi Massimo,
Frisoni Giovanni B.,
Fellgiebel Andreas,
Bokde Arun,
Klöppel Stefan,
Froelich Lutz,
Barkhof Frederik,
Dubois Bruno,
Hampel Harald
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.072
Subject(s) - tractography , diffusion mri , neuroimaging , neuroscience , normality , dementia , psychology , cognition , white matter , magnetic resonance imaging , disease , medicine , pathology , psychiatry , radiology
without. Conclusions: Microinfarcts are associated with an increased rate of brain atrophy independent of AD pathology in the precuneus, primary motor, and primary somatosensory cortices. The increased gray matter loss in these regions occurs at the border zones of the major vascular territories, which are areas that are susceptible to ischemia (Figure 1B). Regional microinfarct pathology is associated with increased rates of GMvolume loss on antemortem MRI.