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IC‐P‐064: COMPARING CONVERSION FROM MILD COGNITIVE IMPAIRMENT TO ALZHEIMER'S DISEASE IN DIFFERENT COHORTS
Author(s) -
Hall Anette,
MuñozRuiz Miguel Ángel,
Mattila Jussi,
Koikkalainen Juha,
Tsolaki Magda,
Mecocci Patrizia,
Kloszewska Iwona,
Vellas Bruno,
Lovestone Simon,
Visser Pieter Jelle,
Lötjönen Jyrki,
Soininen Hilkka
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.069
Subject(s) - cohort , medicine , voxel , neuropsychology , cognition , radiology , psychiatry
1⁄40.001) and body/occipital horn ventriculomegaly (left p corrected1⁄40.003, right p corrected1⁄40.002). Trend significant effects of MS4A6Awere found for the temporal horns (right p corrected1⁄40.053, left p corrected1⁄40.07) and BIN1 for the right temporal (p corrected1⁄40.06) and left frontal (p corrected 1⁄40.09) horns. Conclusions:MCI subjects predestined to develop dementia showed significantly larger ventricles relative to both stable MCI and NC at baseline. The differences between stable MCI and those who developed dementia at follow-up localized to the frontal and body/occipital horn. The groups had comparable temporal horns’ radial distance suggesting a similar degree of neurodegenerative changes (hippocampal and temporal lobe atrophy) between the two groups.